Article

Kappa opioid receptors regulate cocaine effects on nucleus accumbens dopamine through phosphorylation of dopamine transporter at the threonine 53 site

2026-05-11

Abstract excerpt

Chronic cocaine exposure leads to tolerance of the dopamine transporter (DAT) to cocaine and heightened kappa opioid receptor (KOR)-induced inhibition of dopamine (DA) release in the nucleus accumbens (NAc). KORs on presynaptic DA terminals inhibit DA release and modulate DAT function, but whether KOR signaling causes DAT tolerance is unknown. We demonstrate that rats self-administering cocaine escalate their inta...

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Literature Corpus work: 3b4eec3a-4e80-5524-bfa9-ba73ad4c8b0c
DOI: 10.64898/2026.05.06.722744

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Kappa opioid receptors regulate cocaine effects on nucleus accumbens dopamine through phosphorylation of dopamine transporter at the threonine 53 siteDOI 10.64898/2026.05.06.722744Read

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