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Article

Reversal of cocaine-evoked synaptic potentiation resets drug-induced adaptive behaviour.

Nature - 7 Dec 2011

Pascoli Vincent, Turiault Marc, Lüscher Christian

Abstract excerpt

Drug-evoked synaptic plasticity is observed at many synapses and may underlie behavioural adaptations in addiction. Mechanistic investigations start with the identification of the molecular drug targets. Cocaine, for example, exerts its reinforcing and early neuroadaptive effects by inhibiting the dopamine transporter, thus causing a strong increase in mesolimbic dopamine. Among the many signalling pathways...

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PMID: 22158102
DOI: 10.1038/nature10709

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