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Article

Cocaine-evoked negative symptoms require AMPA receptor trafficking in the lateral habenula.

Nature neuroscience - 1 Mar 2015

Meye Frank J, Valentinova Kristina, Lecca Salvatore, Marion-Poll Lucile, Maroteaux Matthieu J, Musardo Stefano, Moutkine Imane, Gardoni Fabrizio, Huganir Richard L, Georges François, Mameli Manuel

Abstract excerpt

Addictive substances mediate positive and negative states promoting persistent drug use. However, substrates for aversive effects of drugs remain elusive. We found that, in mouse lateral habenula (LHb) neurons targeting the rostromedial tegmental nucleus, cocaine enhanced glutamatergic transmission, reduced K(+) currents and increased excitability. GluA1 trafficking in LHb was instrumental for these...

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Identifiers

PMID: 25643299
DOI: 10.1038/nn.3923
PMCID: PMC4357267

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