Article

Generation and characterization of humanization CD4 knock-in mice expressing chimeric mouse/human CD4 protein

2024-05-22

Abstract excerpt

<title>Abstract</title> <p>Humanized mouse models have become indispensable tools for investigating human gene function and disease modeling. However, conventional transgenic approaches carry the risk of unforeseen biological consequences. To address this concern, we developed a novel human <italic>CD4</italic> knock-in mouse model (hCD4 KI mice) using CRISPR/Cas9 gene editing technology. We replaced the region e...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 3b4747b7-e5b6-5e1a-a44b-535196ad1892
DOI: 10.21203/rs.3.rs-4299701/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Generation and characterization of humanization CD4 knock-in mice expressing chimeric mouse/human CD4 proteinDOI 10.21203/rs.3.rs-4299701/v1Read

A human mutant CD4 molecule resistant to HIV-1 binding restores helper T-lymphocyte functions in murine CD4-deficient mice.Semantic proximity Read

A scalable two-step genome editing strategy for generating full-length gene-humanized mice at diverse genomic loci.Semantic proximity Read

Establishment of a Reverse Genetics System for the Study of Human Immune Functions in MiceSemantic proximity Read

Humanized Mice Reveal New Insights Into the Thymic Selection of Human Autoreactive CD8+ T CellsSemantic proximity Read

Human CD1d knock-in mouse model demonstrates potent antitumor potential of human CD1d-restricted invariant natural killer T cellsSemantic proximity Read

Generation of Functional Human T Cell Development in NOD/SCID/IL2rγ <sup>null</sup> Humanized Mice Without Using Fetal Tissue: Application as a Model of HIV Infection and PersistenceSemantic proximity Read

A Subset of CD8αβ+ Invariant NKT Cells in a Humanized Mouse Model.Semantic proximity Read

CRISPR/Cas-Based Gene Editing Strategies for DOCK8 Immunodeficiency SyndromeSemantic proximity Read

Development of a Novel Human CD147 Knock-in NSG Mouse Model to Test SARS-CoV-2 Viral InfectionSemantic proximity Read

A Cre-driven allele-conditioning line to interrogate CD4+ conventional T cells.Semantic proximity Read

A Novel Therapeutic Approach using CXCR3 Blockade to Treat Immune Checkpoint Inhibitor-mediated MyocarditisSemantic proximity Read

Construction and phenotypic analysis of mice carrying a duplication of the major histocompatibility class I (MHC-I) locus.Semantic proximity Read