Article
A Cre-driven allele-conditioning line to interrogate CD4+ conventional T cells.
Immunity - 12 Oct 2021
Andrews Lawrence P, Vignali Kate M, Szymczak-Workman Andrea L, Burton Amanda R, Brunazzi Erin A, Ngiow Shin Foong, Harusato Akihito, Sharpe Arlene H, Wherry E John, Taniuchi Ichiro, Workman Creg J, Vignali Dario A A
Abstract excerpt
CD4+ T cells share common developmental pathways with CD8+ T cells, and upon maturation, CD4+ T conventional T (Tconv) cells lack phenotypic markers that distinguish these cells from FoxP3+ T regulatory cells. We developed a tamoxifen-inducible ThPOKCreERT2.hCD2 line with Frt sites inserted on either side of the CreERT2-hCD2 cassette, and a Foxp3Ametrine-FlpO strain, expressing Ametrine and FlpO in Foxp3+ cells....
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