Article

Development of a Novel Human CD147 Knock-in NSG Mouse Model to Test SARS-CoV-2 Viral Infection

2022-04-20

Abstract excerpt

<title>Abstract</title> <p><bold>Background:</bold> An animal model that can mimic the SARS-CoV-2 infection in humans is critical to understanding the rapidly evolving SARS-CoV-2 virus and for development of prophylactic and therapeutic strategies to combat emerging mutants. Studies show that the spike proteins of SARS-CoV and SARS-CoV-2 bind to human angiotensin-converting enzyme 2 (hACE2, a well-recognized, fun...

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Literature Corpus work: 01c1f161-47ee-5824-bc43-3c36e2c321d0
DOI: 10.21203/rs.3.rs-1431484/v1

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