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A Novel Therapeutic Approach using CXCR3 Blockade to Treat Immune Checkpoint Inhibitor-mediated Myocarditis

2024-02-02

Abstract excerpt

<h4>Background</h4> Immune checkpoint inhibitors (ICIs) are successful in treating many cancers but may cause immune-related adverse events. ICI-mediated myocarditis has a high fatality rate of up to 40%, with severe cardiovascular consequences. Targeted therapies for ICI myocarditis are currently lacking. <h4>Methods</h4> We used a genetic mouse model of PD-1 deletion ( MRL/Pdcd1-/- ) along with a novel drug-...

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Literature Corpus work
c7ca221f-4683-5ede-a090-eda9271b65c4
DOI
10.1101/2024.01.30.576279
Open publication

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A Novel Therapeutic Approach using CXCR3 Blockade to Treat Immune Checkpoint Inhibitor-mediated MyocarditisDOI 10.1101/2024.01.30.576279
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