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Article

A human mutant CD4 molecule resistant to HIV-1 binding restores helper T-lymphocyte functions in murine CD4-deficient mice.

Experimental & molecular medicine - 28 Feb 2007

Kim Dong-Ku, Tahara-Hanaoka Satoko, Satoko Tahara-Hanaoka, Shinohara Nobukata, Shinohara Nobutsuna, Nakauchi Hiromitsu

Abstract excerpt

CD4 is a cell surface glycoprotein that acts as a co-receptor for the T cell antigen receptor by binding to a non-polymorphic portion of MHC molecules. CD4 also functions as a receptor for human immunodeficiency virus type-I (HIV-1) because the viral envelope glycoprotein gp120 binds to CD4 with a high affinity. We have previously demonstrated that introduction of mutations into CD4 abolished the binding of gp120...

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Share to CD4 Antigens
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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to HIV Envelope Protein gp120

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Share to T-Lymphocytes, Helper-Inducer

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Source

Identifiers

PMID: 17334223
DOI: 10.1038/emm.2007.1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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