A human mutant CD4 molecule resistant to HIV-1 binding restores helper T-lymphocyte functions in murine CD4-deficient mice.

doi:10.1038/emm.2007.1

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Article

A human mutant CD4 molecule resistant to HIV-1 binding restores helper T-lymphocyte functions in murine CD4-deficient mice.

Experimental & molecular medicine - 28 Feb 2007

Kim Dong-Ku, Tahara-Hanaoka Satoko, Satoko Tahara-Hanaoka, Shinohara Nobukata, Shinohara Nobutsuna, Nakauchi Hiromitsu

Abstract excerpt

CD4 is a cell surface glycoprotein that acts as a co-receptor for the T cell antigen receptor by binding to a non-polymorphic portion of MHC molecules. CD4 also functions as a receptor for human immunodeficiency virus type-I (HIV-1) because the viral envelope glycoprotein gp120 binds to CD4 with a high affinity. We have previously demonstrated that introduction of mutations into CD4 abolished the binding of gp120...

Topics

Animals
CD4 Antigens
HIV Envelope Protein gp120
HIV-1
Humans
Mice
Mice, Transgenic
Mutation
Protein Binding
T-Lymphocytes, Helper-Inducer
Virus Internalization

Source

Open in PubMed

Identifiers

PMID: 17334223
DOI: 10.1038/emm.2007.1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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