Article

Establishment of a Reverse Genetics System for the Study of Human Immune Functions in Mice

2025-03-31

Abstract excerpt

Reverse genetics approaches in mice are widely utilized to understand gene functions and their aberrations in diseases. However, limitations exist in translating findings from animal models to human physiology. Humanized mice provide a powerful bridge to understanding human physiology and mechanisms of diseases pathogenesis while maintaining the feasibility of working with small animals. Methods for generating hum...

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Literature Corpus work: 73cd1e34-740b-5ab7-bbec-f5cd4461b395
DOI: 10.1101/2025.03.26.645295

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