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Article

Construction and phenotypic analysis of mice carrying a duplication of the major histocompatibility class I (MHC-I) locus.

Mammalian genome : official journal of the International Mammalian Genome Society - 1 Aug 2012

Ermakova Olga, Salimova Ekaterina, Piszczek Lukasz, Gross Cornelius

Abstract excerpt

Copy number variation (CNV) has been associated increasingly with altered susceptibility to human disease. Large CNVs are likely to incur disease risk or resilience via predictable changes in gene dosage that are relatively straightforward to model using chromosomal engineering in mice. The class...

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Identifiers

PMID: 22772436
DOI: 10.1007/s00335-012-9401-7

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22772436-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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