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Acellular normothermic spleen perfusion resolves transcriptional and non-transcriptional mechanisms of steroid immunosuppression

2026-05-19

Abstract excerpt

The limiting step in immune-active drug development is increasingly not candidate generation but testing whether a candidate therapy is effective in a system that preserves tissue architecture, vascular exposure, multicellular interaction, and repeated pharmacodynamic sampling without patient exposure. We developed an acellular normothermic machine-perfusion platform for intact porcine spleen designed as a transla...

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Literature Corpus work
3b3795ab-7911-58fe-81d5-f53347e88e51
DOI
10.64898/2026.05.16.725632
Open publication

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Acellular normothermic spleen perfusion resolves transcriptional and non-transcriptional mechanisms of steroid immunosuppressionDOI 10.64898/2026.05.16.725632
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