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An Accessible Recirculating Organ-on-a-Chip Model of Pregnancy-Associated Breast Cancer Reveals ER Stress-Driven Tumour-Placental Cross-Talk

2026-07-15

Abstract excerpt

<title>Abstract</title> <p>Pregnancy-associated breast cancer (PABC) is more aggressive and has a poorer prognosis than non-pregnant breast cancer, yet no preclinical model recapitulates the tumour-placental cross-talk underlying the disease, a major barrier to developing therapies safe for both mother and fetus. We address this with an accessible PABC organ-on-a-chip model built from commercial components. Two s...

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Literature Corpus work: 0ad643ca-faab-5b81-883d-a14aa6fb81e7
DOI: 10.21203/rs.3.rs-10018077/v1

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