Back to search

Article

Investigation of the transcriptional profile of human kidneys during machine perfusion reveals potential benefits of haemoadsorption

2019-01-16

Abstract excerpt

Transplantation is the optimal treatment for most patients with end stage kidney disease but organ shortage is a major challenge. Normothermic machine perfusion (NMP) has been used to re-condition marginal organs but the mechanisms by which NMP might benefit transplant kidneys are not fully understood. Furthermore, the question of whether removal of pro-inflammatory mediators from the perfusate might offer additio...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
fc3bae98-dc0d-51d2-a33e-ca9caf9ca48d
DOI
10.1101/521294
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Investigation of the transcriptional profile of human kidneys during machine perfusion reveals potential benefits of haemoadsorptionDOI 10.1101/521294
A comparative analysis of acellular versus red cell based subnormothermic machine perfusion in human kidney transplantationSemantic proximity
Transcriptomic profiling during normothermic machine perfusion of human kidneys reveals a pro-inflammatory cellular landscape and gene expression signature associated with prolonged delayed graft function after transplantationSemantic proximity
End of preservation normothermic machine perfusion of porcine kidneys after ischaemic injury reprograms metabolism and induces fibrosis after transplant despite unchanged function: insights from the renal proteomeSemantic proximity
Identification of ferroptosis-associated genes exhibited in human kidney biopsies after one hour of normothermic machine perfusionSemantic proximity
Transcriptomic signatures during normothermic liver machine perfusion correspond with graft quality and predict the early graft functionSemantic proximity
Chronic renoprotective effect of pulsatile perfusion machine RM3 and IGL-1 solution in a preclinical kidney transplantation model.Semantic proximity
PHENOTYPING REPAIR AFTER ACUTE KIDNEY INJURY: PRECISION MEDICINE TO CLINICAL TRIALS.Semantic proximity
Normothermic human kidney preservation drives iron accumulation and ferroptosisSemantic proximity
Hypoxic injury triggers maladaptive repair in human kidney organoidsSemantic proximity
Spatiotemporal transcriptomic analysis during cold ischemic injury to the murine kidney reveals compartment-specific changesSemantic proximity
Orthobiologic-mediated Tissue Regeneration in Chronic Kidney Disease—Phase I Clinical Trial Prospectus and Study ProtocolSemantic proximity
Comparative analysis of kidney transplantation modeled using precision-cut kidney slices and kidney transplantation in pigsSemantic proximity
Select a neighboring publication to make it the new centre.