Article

Genomic Variability of the HCT116 Cell Line Identified Using Oxford Nanopore Sequencing

2026-04-24

Abstract excerpt

HCT116 is a colorectal cancer cell line frequently used in anti-tumor drug development experiments as well as in studies of the molecular machinery of eukaryotic cells. It is well characterized by the presence of several single-nucleotide and short mutations in multiple oncogenes and tumor suppressor genes, including KRAS, PIK3CA, MLH1, CTNNB1, CDKN2A, TGFBR2 , and BRCA2 . However, its landscape of large genomic...

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Literature Corpus work: 3b1e2d7e-1639-5c6b-88d5-77bdafe046c5
DOI: 10.64898/2026.04.23.720331

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