Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Multi-region and single-cell sequencing reveal variable genomic heterogeneity in rectal cancer.

BMC cancer - 23 Nov 2017

Liu Mingshan, Liu Yang, Di Jiabo, Su Zhe, Yang Hong, Jiang Beihai, Wang Zaozao, Zhuang Meng, Bai Fan, Su Xiangqian

Abstract excerpt

BACKGROUND: Colorectal cancer is a heterogeneous group of malignancies with complex molecular subtypes. While colon cancer has been widely investigated, studies on rectal cancer are very limited. Here, we performed multi-region whole-exome sequencing and single-cell whole-genome sequencing to examine the genomic intratumor heterogeneity (ITH) of rectal tumors. METHODS: We sequenced nine tumor regions and 88...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cluster Analysis
Share to DNA Copy Number Variations

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Exome Sequencing

Share to Genetic Heterogeneity

Share to Genomics

Share to Organ Specificity

Share to Rectal Neoplasms

Share to Single-Cell Analysis

Source

Open in PubMed Open full text

Identifiers

PMID: 29169336
DOI: 10.1186/s12885-017-3777-4
PMCID: PMC5701298

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Multi-region and single-cell sequencing reveal variable genomic heterogeneity in rectal cancer.PMID 29169336Read ↗

Intra-tumor genetic heterogeneity in rectal cancer.Semantic proximity Read ↗

Application of Single-Cell Sequencing Technology in Research on Colorectal CancerSemantic proximity Read ↗

Intratumoral Genetic Heterogeneity in Rectal Cancer: Are Single Biopsies representative of the entirety of the tumor?Semantic proximity Read ↗

Single-cell profiling of the copy-number heterogeneity in colorectal cancer.Semantic proximity Read ↗

A Portrait of Intratumoral Genomic and Transcriptomic Heterogeneity at Single-Cell Level in Colorectal CancerSemantic proximity Read ↗

Single-cell sequencing technology in colorectal cancer: a new technology to disclose the tumor heterogeneity and target precise treatmentSemantic proximity Read ↗

Understanding the cellular and molecular heterogeneity in colorectal cancer through the use of single-cell RNA sequencingSemantic proximity Read ↗

Colorectal Cancer Genetic Heterogeneity Delineated by Multi-Region Sequencing.Semantic proximity Read ↗

Bulk and Single-Cell Next-Generation Sequencing: Individualizing Treatment for Colorectal CancerSemantic proximity Read ↗

Single-Cell Multiomics Sequencing Reveals Prevalent Genomic Alterations in Tumor Stromal Cells of Human Colorectal CancerSemantic proximity Read ↗

Single-cell and bulk transcriptome sequencing identifies two epithelial tumor cell states and refines the consensus molecular classification of colorectal cancerSemantic proximity Read ↗

Subclonal Genomic Architectures of Primary and Metastatic Colorectal Cancer Based on Intratumoral Genetic Heterogeneity.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.