Exome Sequencing Reveals AMER1 as a Frequently Mutated Gene in Colorectal Cancer.

doi:10.1158/1078-0432.CCR-15-0159

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Article

Exome Sequencing Reveals AMER1 as a Frequently Mutated Gene in Colorectal Cancer.

Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Oct 2015

Sanz-Pamplona Rebeca, Lopez-Doriga Adriana, Paré-Brunet Laia, Lázaro Kira, Bellido Fernando, Alonso M Henar, Aussó Susanna, Guinó Elisabet, Beltrán Sergi, Castro-Giner Francesc, Gut Marta, Sanjuan Xavier, Closa Adria, Cordero David, Morón-Duran Francisco D, Soriano Antonio, Salazar Ramón, Valle Laura, Moreno Victor

Abstract excerpt

PURPOSE: Somatic mutations occur at early stages of adenoma and accumulate throughout colorectal cancer progression. The aim of this study was to characterize the mutational landscape of stage II tumors and to search for novel recurrent mutations likely implicated in colorectal cancer tumorigenesis. EXPERIMENTAL DESIGN: The exomic DNA of 42 stage II, microsatellite-stable colon tumors and their paired mucosae...

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Identifiers

PMID: 26071483
DOI: 10.1158/1078-0432.CCR-15-0159
PMCID: PMC4609254

Genes

AMER1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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