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SMOOTH-seq: single-cell genome sequencing of human cells on a third-generation sequencing platform.

Genome biology - 30 Jun 2021

Fan Xiaoying, Yang Cheng, Li Wen, Bai Xiuzhen, Zhou Xin, Xie Haoling, Wen Lu, Tang Fuchou

Abstract excerpt

There is no effective way to detect structure variations (SVs) and extra-chromosomal circular DNAs (ecDNAs) at single-cell whole-genome level. Here, we develop a novel third-generation sequencing platform-based single-cell whole-genome sequencing (scWGS) method named SMOOTH-seq (single-molecule real-time sequencing of long fragments amplified through transposon insertion). We evaluate the method for detecting...

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Identifiers

PMID: 34193237
DOI: 10.1186/s13059-021-02406-y
PMCID: PMC8247186

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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