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Colorectal Cancer Cell Lines Are Representative Models of the Main Molecular Subtypes of Primary Cancer

23 Apr 2014

Abstract excerpt

Human colorectal cancer cell lines are used widely to investigate tumor biology, experimental therapy, and biomarkers. However, to what extent these established cell lines represent and maintain the genetic diversity of primary cancers is uncertain. In this study, we profiled 70 colorectal cancer cell lines for mutations and DNA copy number by whole-exome sequencing and SNP microarray analyses, respectively. Gene...

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PMID: 24755471
DOI: 10.1158/0008-5472.can-14-0013

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