Article

Inhibition of TXNRD or SOD1 overcomes NRF2-mediated resistance to β-lapachone

2019-11-25

Abstract excerpt

Alterations in the NRF2/KEAP1 pathway result in the constitutive activation of NRF2, leading to the aberrant induction of antioxidant and detoxification enzymes, including NQO1. The NQO1 bioactivatable agent β-lapachone can target cells with high NQO1 expression but relies in the generation of reactive oxygen species (ROS), which are actively scavenged in cells with NRF2/KEAP1 mutations. However, whether NRF2/KEAP...

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Literature Corpus work: 3b1bece4-8982-5cf0-bc32-8beaa0acc8b5
DOI: 10.1101/849927

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