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Article

Inhibition of TXNRD or SOD1 overcomes NRF2-mediated resistance to β-lapachone.

Redox biology - 1 Feb 2020

Torrente Laura, Prieto-Farigua Nicolas, Falzone Aimee, Elkins Cody M, Boothman David A, Haura Eric B, DeNicola Gina M

Abstract excerpt

Alterations in the NRF2/KEAP1 pathway result in the constitutive activation of NRF2, leading to the aberrant induction of antioxidant and detoxification enzymes, including NQO1. The NQO1 bioactivatable agent β-lapachone can target cells with high NQO1 expression but relies in the generation of reactive oxygen species (ROS), which are actively scavenged in cells with NRF2/KEAP1 mutations. However, whether...

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Identifiers

PMID: 32007910
DOI: 10.1016/j.redox.2020.101440
PMCID: PMC6997906

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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