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Article

Emerging role of NRF2 in chemoresistance by regulating drug-metabolizing enzymes and efflux transporters.

Drug metabolism reviews - 1 Nov 2016

Bai Xupeng, Chen Yibei, Hou Xiangyu, Huang Min, Jin Jing

Abstract excerpt

Chemoresistance is a disturbing barrier in cancer therapy, which always results in limited therapeutic options and unfavorable prognosis. Nuclear factor E2-related factor 2 (NRF2) controls the expression of genes encoding cytoprotective enzymes and transporters that protect against oxidative stress and electrophilic injury to maintain intrinsic redox homeostasis. However, recent studies have demonstrated that...

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Identifiers

PMID: 27320238
DOI: 10.1080/03602532.2016.1197239

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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