Article
RNAi-mediated silencing of nuclear factor erythroid-2-related factor 2 gene expression in non-small cell lung cancer inhibits tumor growth and increases efficacy of chemotherapy.
Cancer research - 1 Oct 2008
Singh Anju, Boldin-Adamsky Swetlana, Thimmulappa Rajesh K, Rath Srikanta K, Ashush Hagit, Coulter Jonathan, Blackford Amanda, Goodman Steven N, Bunz Fred, Watson Walter H, Gabrielson Edward, Feinstein Elena, Biswal Shyam
Abstract excerpt
Nuclear factor erythroid-2-related factor 2 (Nrf2) is a redox-sensitive transcription factor that regulates the expression of electrophile and xenobiotic detoxification enzymes and efflux proteins, which confer cytoprotection against oxidative stress and apoptosis in normal cells. Loss of function mutations in the Nrf2 inhibitor, Kelch-like ECH-associated protein (Keap1), results in constitutive activation of...
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