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Article

Modification of platinum sensitivity by KEAP1/NRF2 signals in non-small cell lung cancer.

Journal of hematology & oncology - 6 Sept 2016

Tian Yijun, Wu Kongming, Liu Qian, Han Na, Zhang Li, Chu Qian, Chen Yuan

Abstract excerpt

BACKGROUND: The objective of this study was to evaluate the effect of platinum-based drugs on nuclear-factor erythroid2 like 2 (NRF2) signaling in non-small cell lung cancer cell lines with or without Kelch-like ECH-associated protein 1 (KEAP1) mutations and to determine the role of NRF2 and KEAP1 on platinum-based drug treatment. METHODS: We used real-time PCR to assess relative mRNA expression and used western...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 27601007
DOI: 10.1186/s13045-016-0311-0
PMCID: PMC5012055

Genes

KEAP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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