Article

Small Molecule Screen Identifies Pyrimethamine as an Inhibitor of NRF2-driven Esophageal Hyperplasia

2022-12-08

Abstract excerpt

<h4>Objective</h4> NRF2 is a master transcription factor that regulates the stress response. NRF2 is frequently mutated and activated in human esophageal squamous cell carcinoma (ESCC), which drives resistance to chemotherapy and radiation therapy. Therefore, a great need exists for NRF2 inhibitors for targeted therapy of NRF2 high ESCC. <h4>Design</h4> We performed high-throughput screening of two compound li...

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Literature Corpus work: 606ac491-d159-540f-bb5a-4e8fe5ffb0be
DOI: 10.1101/2022.12.05.519147

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