Article

MCB-613 exploits a collateral sensitivity in drug resistant <i>EGFR</i> -mutant non-small cell lung cancer through covalent inhibition of KEAP1

2023-01-19

Abstract excerpt

<h4>ABSTRACT</h4> Targeted therapies have revolutionized cancer chemotherapy. Unfortunately, most patients develop multifocal resistance to these drugs within a matter of months. Here, we used a high-throughput phenotypic small molecule screen to identify MCB-613 as a compound that selectively targets EGFR -mutant, EGFR inhibitor-resistant non-small cell lung cancer (NSCLC) cells harboring diverse resistance mec...

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Literature Corpus work: 1dfba0fd-5385-50ab-b3ad-00935c7a7a34
DOI: 10.1101/2023.01.17.524094

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