Article

Tumor-intrinsic LKB1-LIF signaling axis establishes a myeloid niche to promote immune evasion and tumor growth

2023-07-17

Abstract excerpt

<h4>SUMMARY</h4> Tumor mutations can influence the surrounding microenvironment leading to suppression of anti-tumor immune responses and thereby contributing to tumor progression and failure of cancer therapies. Here we use genetically engineered lung cancer mouse models and patient samples to dissect how LKB1 mutations accelerate tumor growth by reshaping the immune microenvironment. Comprehensive immune profi...

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Literature Corpus work: 3b0efb07-2551-52d3-beba-6af4f227bc2e
DOI: 10.1101/2023.07.15.549147

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