MCT4-dependent lactate secretion suppresses antitumor immunity in LKB1-deficient lung adenocarcinoma.

doi:10.1016/j.ccell.2023.05.015

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Article

MCT4-dependent lactate secretion suppresses antitumor immunity in LKB1-deficient lung adenocarcinoma.

Cancer cell - 10 Jul 2023

Qian Yu, Galan-Cobo Ana, Guijarro Irene, Dang Minghao, Molkentine David, Poteete Alissa, Zhang Fahao, Wang Qi, Wang Jing, Parra Edwin, Panda Apekshya, Fang Jacy, Skoulidis Ferdinandos, Wistuba Ignacio I, Verma Svena, Merghoub Taha, Wolchok Jedd D, Wong Kwok-Kin, DeBerardinis Ralph J, Minna John D, Vokes Natalie I, Meador Catherine B, Gainor Justin F, Wang Linghua, Reuben Alexandre, Heymach John V

Abstract excerpt

Inactivating STK11/LKB1 mutations are genomic drivers of primary resistance to immunotherapy in KRAS-mutated lung adenocarcinoma (LUAD), although the underlying mechanisms remain unelucidated. We find that LKB1 loss results in enhanced lactate production and secretion via the MCT4 transporter. Single-cell RNA profiling of murine models indicates that LKB1-deficient tumors have increased M2 macrophage polarization...

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Identifiers

PMID: 37327788
DOI: 10.1016/j.ccell.2023.05.015
PMCID: PMC11161201

Genes

STK11
KRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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