Article
LIF-Induced Tumor Plasticity Establishes an Immunosuppressive Myeloid Niche in LKB1-Mutant Lung Cancer.
Cancer discovery - 1 Jul 2026
Pillai Ray, Rashidfarrokhi Ali, Hao Yuan, Wu Warren L, Mancini Mariana C S, Karadal-Ferrena Burcu, Dimitriadoy Sofia G, Cross Michael, Yeaton Anna H, Huang Shih Ming, Bhutkar Arjun, Herrera Alberto M, Rajalingam Sahith, Hayashi Makiko, Huang Kuan-Lin, Bartnicki Eric, Zavitsanou Anastasia-Maria, Ivanova Ellie, Wohlhieter Corrin, LeBoeuf Sarah E, Chen Ting, Loomis Cynthia A, Kulicke Ruth, Davis Fred P, Stransky Nicolas, Smolen Gromoslaw Aleksander, Tsay Jun-Chieh J, Simabuco Fernando Moreira, Rudin Charles M, Moreira Andre L, Khanna Kamal M, Pass Harvey I, Wong Kwok-Kin, Koide Shohei, Tsirigos Aristotelis, Koralov Sergei B, Papagiannakopoulos Thales
Abstract excerpt
LKB1 mutations in lung cancer promote an immunosuppressive tumor microenvironment, but the underlying mechanisms remain unknown. Using genetically engineered mouse models and human tumor samples, we demonstrate that LKB1 loss leads to high expression of the cytokine leukemia-inhibitory factor (LIF), which through a cancer cell-autonomous autocrine loop, orchestrates the infiltration of immunosuppressive SiglecFHi...
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