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SiglecF <sup>high</sup> neutrophils in lung tumor tissues suppress local CD8 T cell responses and limit the efficacy of anti PD-L1 antibodies

2021-10-21

Abstract excerpt

<h4>Background</h4> Tumor infiltrating neutrophils generally correlates to worst prognosis and refractoriness to immunotherapy yet the complexity and significance of diverse subsets resident in tumor tissues has just begun to emerge. In lung tumors, a network of neutrophils states with graded protumorigenic properties is conserved between mouse and humans and include a subset of mature, long lived cells expressin...

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Literature Corpus work
85e06efb-3ec6-5b70-858e-4937928e37e7
DOI
10.1101/2021.10.21.464997
Open publication

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SiglecF <sup>high</sup> neutrophils in lung tumor tissues suppress local CD8 T cell responses and limit the efficacy of anti PD-L1 antibodiesDOI 10.1101/2021.10.21.464997
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