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Article

LKB1 inactivation modulates chromatin accessibility to drive metastatic progression.

Nature cell biology - 1 Aug 2021

Pierce Sarah E, Granja Jeffrey M, Corces M Ryan, Brady Jennifer J, Tsai Min K, Pierce Aubrey B, Tang Rui, Chu Pauline, Feldser David M, Chang Howard Y, Bassik Michael C, Greenleaf William J, Winslow Monte M

Abstract excerpt

Metastasis is the leading cause of cancer-related deaths and enables cancer cells to compromise organ function by expanding in secondary sites. Since primary tumours and metastases often share the same constellation of driver mutations, the mechanisms that drive their distinct phenotypes are unclear. Here we show that inactivation of the frequently mutated tumour suppressor gene LKB1 (encoding liver kinase B1)...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34341533
DOI: 10.1038/s41556-021-00728-4
PMCID: PMC8355205

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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