STK11/LKB1 Deficiency Promotes Neutrophil Recruitment and Proinflammatory Cytokine Production to Suppress T-cell Activity in the Lung Tumor Microenvironment.

doi:10.1158/0008-5472.CAN-15-1439

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Article

STK11/LKB1 Deficiency Promotes Neutrophil Recruitment and Proinflammatory Cytokine Production to Suppress T-cell Activity in the Lung Tumor Microenvironment.

Cancer research - 1 Mar 2016

Koyama Shohei, Akbay Esra A, Li Yvonne Y, Aref Amir R, Skoulidis Ferdinandos, Herter-Sprie Grit S, Buczkowski Kevin A, Liu Yan, Awad Mark M, Denning Warren L, Diao Lixia, Wang Jing, Parra-Cuentas Edwin R, Wistuba Ignacio I, Soucheray Margaret, Thai Tran, Asahina Hajime, Kitajima Shunsuke, Altabef Abigail, Cavanaugh Jillian D, Rhee Kevin, Gao Peng, Zhang Haikuo, Fecci Peter E, Shimamura Takeshi, Hellmann Matthew D, Heymach John V, Hodi F Stephen, Freeman Gordon J, Barbie David A, Dranoff Glenn, Hammerman Peter S, Wong Kwok-Kin

Abstract excerpt

STK11/LKB1 is among the most commonly inactivated tumor suppressors in non-small cell lung cancer (NSCLC), especially in tumors harboring KRAS mutations. Many oncogenes promote immune escape, undermining the effectiveness of immunotherapies, but it is unclear whether the inactivation of tumor suppressor genes, such as STK11/LKB1, exerts similar effects. In this study, we investigated the consequences of...

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Identifiers

PMID: 26833127
DOI: 10.1158/0008-5472.CAN-15-1439
PMCID: PMC4775354

Genes

STK11
KRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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STK11/LKB1 Deficiency Promotes Neutrophil Recruitment and Proinflammatory Cytokine Production to Suppress T-cell Activity in the Lung Tumor Microenvironment.PMID 26833127Read ↗

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