Article

Pharmacological rescue of tumor intrinsic STING expression and immune response in LKB1-mutant lung cancer via the IAP-JAK regulatory axis

2021-09-17

Abstract excerpt

<h4>Summary</h4> Harnessing the power of the immune system to treat cancer has become a core clinical approach. However, rewiring of intrinsic circuitry enables tumor cells to escape immune attacks, leading to therapeutic failure. Pharmacological strategies to reverse tumor genotype-dictated therapeutic resistance are urgently needed to advance precision immunotherapy. Here, we identify antagonists of Inhibitor o...

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Literature Corpus work: f0405fe3-b502-5d47-8280-06d66808b385
DOI: 10.1101/2021.09.17.460294

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Pharmacological rescue of tumor intrinsic STING expression and immune response in LKB1-mutant lung cancer via the IAP-JAK regulatory axisDOI 10.1101/2021.09.17.460294Read

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