Article

Amplification is the Primary Mode of Gene-by-Sex Interaction in Complex Human Traits

2022-05-08

Abstract excerpt

<h4>Summary</h4> Sex differences in complex traits are suspected to be in part due to widespread gene-by-sex interactions (GxSex), but empirical evidence has been elusive. Here, we infer the mixture of ways polygenic effects on physiological traits covary between males and females. We find that GxSex is pervasive but acts primarily through systematic sex differences in the magnitude of many genetic effects (“ampl...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 3afe9879-d3cb-518a-a569-2097bb978e04
DOI: 10.1101/2022.05.06.490973

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Amplification is the Primary Mode of Gene-by-Sex Interaction in Complex Human TraitsDOI 10.1101/2022.05.06.490973Read

Evidence for sex-specific genetic architectures across a spectrum of human complex traits.Semantic proximity Read

Sexual differences in genetic architecture in UK BiobankSemantic proximity Read

Sex differences in genetic architecture in the UK Biobank.Semantic proximity Read

The effect of X-linked dosage compensation on complex trait variationSemantic proximity Read

A Robust Method Uncovers Significant Context-Specific Heritability in Diverse Complex Traits.Semantic proximity Read

Multivariate genetic architecture reveals testosterone-driven sexual antagonism in contemporary humans.Semantic proximity Read

The evolution of sex differences in disease geneticsSemantic proximity Read

Genotype × environment interactions in gene regulation and complex traits.Semantic proximity Read

Genetic association data are broadly consistent with stabilizing selection shaping human common diseases and traitsSemantic proximity Read

A scalable and robust variance components method reveals insights into the architecture of gene-environment interactions underlying complex traitsSemantic proximity Read

Reimagining Gene-Environment Interaction Analysis for Human Complex TraitsSemantic proximity Read

Choice of phenotype scale is critical in biobank-based G×E testsSemantic proximity Read