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Article

Sex differences in genetic architecture in the UK Biobank.

Nature genetics - 1 Sept 2021

Bernabeu Elena, Canela-Xandri Oriol, Rawlik Konrad, Talenti Andrea, Prendergast James, Tenesa Albert

Abstract excerpt

Males and females present differences in complex traits and in the risk of a wide array of diseases. Genotype by sex (GxS) interactions are thought to account for some of these differences. However, the extent and basis of GxS are poorly understood. In the present study, we provide insights into both the scope and the mechanism of GxS across the genome of about 450,000 individuals of European ancestry and 530...

Topics

Biological Specimen Banks
Female
Gene Expression Regulation
Genotype
Humans
Male
Multifactorial Inheritance
Polymorphism, Single Nucleotide
Quantitative Trait Loci
Quantitative Trait, Heritable
Sex Characteristics

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Sex Factors

United Kingdom

Source

Identifiers

PMID: 34493869
DOI: 10.1038/s41588-021-00912-0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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