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Article

Multivariate genetic architecture reveals testosterone-driven sexual antagonism in contemporary humans.

Proceedings of the National Academy of Sciences of the United States of America - 11 Jun 2024

Chakrabarty Anasuya, Chakraborty Saikat, Nandi Diptarup, Basu Analabha

Abstract excerpt

Sex difference (SD) is ubiquitous in humans despite shared genetic architecture (SGA) between the sexes. A univariate approach, i.e., studying SD in single traits by estimating genetic correlation, does not provide a complete biological overview, because traits are not independent and are genetically correlated. The multivariate genetic architecture between the sexes can be summarized by estimating the additive...

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PMID: 38833469
DOI: 10.1073/pnas.2404364121
PMCID: PMC11181031

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