Article

Inactivating Negative Regulators of Cortical Branched Actin Enhances Persistence of Single Cell Migration

2023-05-13

Abstract excerpt

<h4>ABSTRACT</h4> The Rac1-WAVE-Arp2/3 pathway pushes the plasma membrane by polymerizing branched actin at the cell cortex and thereby powering membrane protrusions that mediate cell migration. Here, using knock-down (KD) or knock-out (KO), we combine the inactivation of the Arp2/3 inhibitory protein Arpin, the Arp2/3 subunit ARPC1A and the WAVE complex subunit, CYFIP2, that all enhance the polymerization of cor...

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Literature Corpus work: 3afb49c6-ad7c-55a9-8bbd-57096b3e16a5
DOI: 10.1101/2023.05.13.540631

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