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Article

Oncogenic PIK3CA enhances collective migration of mammary epithelial cells through ERK wave propagation.

Journal of cell science - 1 Aug 2026

Dayoub Ali, Fokin Artem I, Leonov Sergey, Gautreau Alexis M, Alexandrova Antonina Y

Abstract excerpt

Oncogenic mutations of the PIK3CA gene, which encodes the catalytic subunit of the phosphatidylinositol 3-kinase (PI3K) enhance cell migration via ERK (ERK1 and ERK2, also known as MAPK3 and MAPK1, respectively) activation. We analyzed the factors regulating collective cell migration (CCM) of genome-edited MCF10A cell lines carrying hotspot PIK3CA mutations E545K or H1047R. H1047R enhanced CCM and promoted the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 42572841
DOI: 10.1242/jcs.264916

Genes

PIK3CA
MAPK1
MAPK3

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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