Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

RhoA activation during polarization and cytokinesis of the early <i>Caenorhabditis elegans</i> embryo is differentially dependent on NOP-1 and CYK-4

23 Aug 2012

Abstract excerpt

The GTPase RhoA is a central regulator of cellular contractility in a wide variety of biological processes. During these events, RhoA is activated by guanine nucleotide exchange factors (GEFs). These molecules are highly regulated to ensure that RhoA activation occurs at the proper time and place. During cytokinesis, RhoA is activated by the RhoGEF ECT-2. In human cells, ECT-2 activity requires its association...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Genetics, Aging, and Longevity in Model Organisms
Share to Reproductive Biology and Fertility

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 22918944
DOI: 10.1091/mbc.e12-04-0268

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

RhoA activation during polarization and cytokinesis of the early <i>Caenorhabditis elegans</i> embryo is differentially dependent on NOP-1 and CYK-4PMID 22918944Read ↗

CGEF-1 and CHIN-1 regulate CDC-42 activity during asymmetric division in the Caenorhabditis elegans embryo.Semantic proximity Read ↗

Inhibition of Rac by the GAP activity of centralspindlin is essential for cytokinesis.Semantic proximity Read ↗

CYK-4: A Rho family gtpase activating protein (GAP) required for central spindle formation and cytokinesis.Semantic proximity Read ↗

Rho-binding kinase (LET-502) and myosin phosphatase (MEL-11) regulate cytokinesis in the early Caenorhabditis elegans embryo.Semantic proximity Read ↗

Rho Kinases in Embryonic Development and Stem Cell ResearchSemantic proximity Read ↗

Parallel Rap1>RalGEF>Ral and Ras signals sculpt the <i>C. elegans</i> nervous systemSemantic proximity Read ↗

The RhoGAP HUM-7/Myo9 integrates signals to modulate RHO-1/RhoA during embryonic morphogenesis in Caenorhabditis elegansSemantic proximity Read ↗

The Rho guanine exchange factor RHGF-2 acts through the Rho-binding kinase LET-502 to mediate embryonic elongation in C. elegans.Semantic proximity Read ↗

OSGN-1 is a conserved flavin-containing monooxygenase required to stabilize the intercellular bridge in late cytokinesisSemantic proximity Read ↗

PAR-4/LKB1 mobilizes nonmuscle myosin through anillin to regulate C. elegans embryonic polarization and cytokinesis.Semantic proximity Read ↗

The RhoGAP myosin 9/HUM-7 integrates membrane signals to modulate Rho/RHO-1 during embryonic morphogenesis in <i>C. elegans</i>Semantic proximity Read ↗

Rho signaling research: history, current status and future directionsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.