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Article

The PAR complex controls the spatiotemporal dynamics of F-actin and the MTOC in directionally migrating leukocytes.

Journal of cell science - 15 Oct 2014

Crespo Carolina Lage, Vernieri Claudio, Keller Philipp J, Garrè Massimiliano, Bender Jeffrey R, Wittbrodt Joachim, Pardi Ruggero

Abstract excerpt

Inflammatory cells acquire a polarized phenotype to migrate towards sites of infection or injury. A conserved polarity complex comprising PAR-3, PAR-6 and atypical protein kinase C (aPKC) relays extracellular polarizing cues to control cytoskeletal and signaling networks affecting morphological and functional polarization. However, there is no evidence that myeloid cells use PAR signaling to migrate vectorially...

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Identifiers

PMID: 25179599
DOI: 10.1242/jcs.146217
PMCID: PMC4197085

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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