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Article

Restrained activation of CYFIP2-containing WAVE complexes controls membrane protrusions and cell migration

2020-07-03

Abstract excerpt

Branched actin networks polymerized by the Arp2/3 complex are critical for cell migration. The WAVE complex is the machinery that activates Arp2/3 in a RAC1-dependent manner at the leading edge of migrating cells. Multiple WAVE complexes are assembled in a cell through various combinations of paralogous subunits. Here we report the surprising phenotype associated with loss-of-function of CYFIP2, a subunit of the W...

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Identifiers and source

Literature Corpus work
66b7cdee-ccaf-50e3-94af-ab2cf752fb19
DOI
10.1101/2020.07.02.184655
Open publication

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Restrained activation of CYFIP2-containing WAVE complexes controls membrane protrusions and cell migrationDOI 10.1101/2020.07.02.184655
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