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A novel fluorescent strategy for detection of uracil-DNA glycosylase activity based on strand displacement reaction triggered by ligase

2024-08-25

Abstract excerpt

Uracil-DNA glycosylase (UDG) plays a key role in the base repair system, and detecting its enzymatic activity is crucial for early disease diagnosis. A novel nicking enzyme-assisted, high-specificity fluorescent sensor for uracil-DNA glycosylase activity detection is constructed. A DNA probe modified with uracil was utilized to ligate two free DNA strands to form a newly generated DNA strand. This triggers a nicki...

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Literature Corpus work
3ad3cd9f-31c4-5c71-a526-2e60dfa859aa
DOI
10.22541/au.172455278.82192133/v1
Open publication

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