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Article

A far-red emissive two-photon fluorescent probe for quantification of uracil in genomic DNA.

Chemical communications (Cambridge, England) - 16 Mar 2021

Wang Bingyao, Chen Yi, Zhang Xiong, Jiang Zhuoran, Wang Yafen, Chen Kun, Wang Fang, Weng Xiaocheng, Zhou Xiang

Abstract excerpt

We report a new method for dU detection in genomic DNA combined with UNG excision and fluorescent probe labeling. UNG can remove uracil bases to introduce abasic sites, which can react with NRNO to produce intense fluorescence because of the inhibition of the PET effect. It can also cause the polymerase extension to stop to provide details of dU site information.

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PMID: 33599665
DOI: 10.1039/d1cc00016k

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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