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Article

Label-free colorimetric detection of cancer related gene based on two-step amplification of molecular machine.

Biosensors & bioelectronics - 15 Apr 2017

Xu Huo, Wu Dong, Li Chen-Qiao, Lu Zheng, Liao Xiao-Yun, Huang Jie, Wu Zai-Sheng

Abstract excerpt

Highly sensitive detection of K-ras gene is of great significance in biomedical research and clinical diagnosis. Here, we developed a colorimetric biosensing system for the detection of proto-oncogene K-ras based on enhanced amplification effect of DNA molecular machine, where dual isothermal circular strand-displacement amplification (D-SDA) occurs on two arms in one-to-one correspondence. Specifically, we...

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Identifiers

PMID: 27936442
DOI: 10.1016/j.bios.2016.12.003

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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