Article
Statistics of Cellular Evolution in Leukemia: Allelic Variations in Patient Trajectories Based on Immune Repertoire Sequencing
2016-01-25
Abstract excerpt
The evolution of a cancer system consisting of cancer clones and normal cells is a complex dynamic process with multiple interacting factors including clonal expansion, somatic mutation, and sequential selection. As a typical example, in patients with chronic lymphocytic leukemia (CLL), a monoclonal population of transformed B cells expands to dominate the B cell population in the peripheral blood and bone marrow....
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Identifiers and source
- Literature Corpus work
- 3ac86e8e-4d73-58cb-9d1c-be8dd592c2d6
- DOI
- 10.1101/037770