Evolution of chronic lymphocytic leukemia after allogeneic stem cell transplant

Abstract excerpt

<h4>ABSTRACT</h4> Allogeneic stem cell transplant (alloSCT) for patients with relapsed/refractory chronic lymphocytic leukemia (CLL) can result in cure in some patients. Analogous to chemotherapy and targeted therapy, we hypothesized that allogeneic cellular immunotherapies, including alloSCT and donor lymphocyte infusion (DLI), would impact malignant evolution through the application of selective immunologic pre...

Topics

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• CAR-T cell therapy research
• Chronic Lymphocytic Leukemia Research
• Clonal Evolution
• Disease Progression
• Genomics
• High-Throughput Nucleotide Sequencing
• Leukemia, Lymphocytic, Chronic, B-Cell
• Mutation

Identifiers and source

Literature Corpus work

76e4afab-8ca7-55fe-8a05-eec9cb7a70e5

DOI

10.1101/2025.01.22.634212