Article

Mapping the evolution of T cell states during response and resistance to adoptive cellular therapy

2020-07-10

Abstract excerpt

Immune therapies have transformed the cancer therapeutic landscape but fail to benefit most patients. To elucidate the underlying mechanisms by which T cells mediate elimination of leukemia, we generated a high-resolution map of longitudinal T cell dynamics within the same tumor microenvironment (TME) during response or resistance to donor lymphocyte infusion (DLI), a widely used immunotherapy for relapsed leukemi...

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Identifiers and source

Literature Corpus work: c375bf56-3073-503a-862e-85a697f41649
DOI: 10.1101/2020.07.08.194332

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