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Article

Massive evolution of the immunoglobulin heavy chain locus in children with B precursor acute lymphoblastic leukemia

30 Aug 2012

Abstract excerpt

The ability to distinguish clonal B-cell populations based on the sequence of their rearranged immunoglobulin heavy chain (IgH) locus is an important tool for diagnosing B-cell neoplasms and monitoring treatment response. Leukemic precursor B cells may continue to undergo recombination of the IgH gene after malignant transformation; however, the magnitude of evolution at the IgH locus is currently unknown. We...

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PMID: 22932801
DOI: 10.1182/blood-2012-05-429811

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