Article

Structure-guided analysis and prediction of human E2–E3 ligase pairing specificity

2026-02-12

Abstract excerpt

Protein ubiquitination, directed by specific E3 ligases, constitutes the primary cellular pathway for selective protein degradation. In addition to targeting proteins for degradation, ubiquitination can mediate new protein–protein interactions, and otherwise modulate protein function, thereby regulating key cellular processes such as DNA repair and immune responses. Recently, Proteolysis-Targeting Chimeras (PROTAC...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 3ac20d46-a439-5a06-ad00-faeade1c9a45
DOI: 10.64898/2026.02.10.700855

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Structure-guided analysis and prediction of human E2–E3 ligase pairing specificityDOI 10.64898/2026.02.10.700855Read

Expanding PROTACtable genome universe of E3 ligasesSemantic proximity Read

ELiAH: the atlas of E3 ligases in human tissues for targeted protein degradation with reduced off-target effectSemantic proximity Read

A comprehensive framework of E2-RING E3 interactions of the human ubiquitin-proteasome system.Semantic proximity Read

GlueFinder: A Data-Driven Framework for the Rational Discovery of Molecular GluesSemantic proximity Read

A comprehensive primer and review of PROTACs and their In Silico designSemantic proximity Read

Structure-Based Survey of the Human Proteome for Opportunities in Proximity PharmacologySemantic proximity Read

Combinatorial mapping of E3 ubiquitin ligases to their target substratesSemantic proximity Read

BioE3 identifies specific substrates of ubiquitin E3 ligasesSemantic proximity Read

Mining the CRBN Target Space Redefines Rules for Molecular Glue-induced Neosubstrate RecognitionSemantic proximity Read

Structure of the human FANCL RING-Ube2T complex reveals determinants of cognate E3-E2 selection.Semantic proximity Read

Rational Prediction of PROTAC-compatible Protein-Protein Interfaces by Molecular DockingSemantic proximity Read

Dynamic interactions of proteins in complex networks: identifying the complete set of interacting E2s for functional investigation of E3‐dependent protein ubiquitinationSemantic proximity Read