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Article

Structure of the human FANCL RING-Ube2T complex reveals determinants of cognate E3-E2 selection.

Structure (London, England : 1993) - 4 Feb 2014

Hodson Charlotte, Purkiss Andrew, Miles Jennifer Anne, Walden Helen

Abstract excerpt

The combination of an E2 ubiquitin-conjugating enzyme with an E3 ubiquitin-ligase is essential for ubiquitin modification of a substrate. Moreover, the pairing dictates both the substrate choice and the modification type. The molecular details of generic E3-E2 interactions are well established. Nevertheless, the determinants of selective, specific E3-E2 recognition are not understood. There are ∼40 E2s and ∼600...

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Source

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Identifiers

PMID: 24389026
DOI: 10.1016/j.str.2013.12.004
PMCID: PMC3979106

Genes

FANCL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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