Dynamic interactions of proteins in complex networks: identifying the complete set of interacting E2s for functional investigation of E3‐dependent protein ubiquitination

Abstract excerpt

A ubiquitin ligase (E3) functions at the crossroad between ubiquitin activation and the attachment of ubiquitin to protein substrates. During this process, the E3 interacts with both a substrate and a ubiquitin-conjugating enzyme (E2). Although a major goal when investigating an E3 is to identify its substrates, recent evidence indicates that the E2 dictates the type of ubiquitin modification that will occur on...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Cancer-related Molecular Pathways
• Share to Mitochondrial Function and Pathology
• Share to Ubiquitin and proteasome pathways